LFA-1: Key Protein Involved in Cell Adhesion and Migration (P5753)

Target Name: Integrin alphaLbeta2 (LFA-1) receptor

NCBI ID: P5753

Integrin alphaLbeta2 (LFA-1) receptor

Other Name(s): Leukocyte function-associated antigen-1 | Lymphocyte function-associated antigen-1 | CD11a/CD18 | LFA-1

LFA-1: Key Protein Involved in Cell Adhesion and Migration

Integrin alphaLbeta2 (LFA-1) receptor, also known as Leukocyte function-associated antigen-1 (LFA-1), is a protein that is expressed in various cell types, including leukocytes, thymus, and epithelial cells. It is a member of the integrin family, which is a group of transmembrane proteins that play a critical role in cell-cell and cell-extracellular matrix interactions. LFA-1 is involved in many different cellular processes, including cell adhesion, migration, and signaling.

One of the key functions of LFA-1 is its role in cell adhesion. LFA-1 is involved in the formation of tight junctions, which are specialized junctions that form between adjacent cells and help to maintain tissue integrity. These junctions are critical for the proper functioning of various tissues, including blood vessels, epithelial tissues, and the nervous system.

Another important function of LFA-1 is its role in cell migration. LFA-1 is involved in the regulation of cell movement, allowing cells to move and divide in a precise and controlled manner. This is important for the development and maintenance of tissues and organs, as well as for the immune response.

In addition to its role in cell adhesion and migration, LFA-1 is also involved in many signaling pathways. For example, LFA-1 has been shown to play a role in the regulation of angiogenesis, the formation of new blood vessels, and the regulation of inflammation.

Despite its many important functions, LFA-1 is also a potential drug target. Many studies have suggested that LFA-1 may be a useful target for the development of new treatments for various diseases, including cancer, cardiovascular disease, and autoimmune disorders.

One of the reasons for the potential of LFA-1 as a drug target is its involvement in multiple signaling pathways. As mentioned above, LFA-1 is involved in the regulation of cell adhesion, migration, and signaling, making it a potential target for drugs that can modulate these processes. Additionally, LFA-1 has been shown to play a role in the regulation of angiogenesis, which is the formation of new blood vessels. This suggests that LFA-1 may be a useful target for drugs that can modulate blood vessel formation and function.

Another potential target for LFA-1 is its role in the regulation of inflammation. LFA-1 has been shown to play a role in the regulation of immune cell function and the regulation of inflammatory responses. This suggests that LFA-1 may be a useful target for drugs that can modulate these processes.

In addition to its potential as a drug target, LFA-1 is also a potential biomarker. The expression of LFA-1 has been shown to be associated with various diseases, including cancer, cardiovascular disease, and autoimmune disorders. This suggests that LFA-1 may be a useful biomarker for the diagnosis and treatment of these diseases.

Overall, LFA-1 is a complex and important protein that is involved in many different cellular processes. Its potential as a drug target and biomarker make it an attractive target for researchers to explore. Further studies are needed to fully understand the role of LFA-1 in cell biology and its potential as a therapeutic agent.

Protein Name: Integrin AlphaLbeta2 (LFA-1) Receptor

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